The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Nov. 23, 2016
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Peter T. Sage, Brookline, MA (US);
Arlene H. Sharpe, Brookline, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 35/26 (2015.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); A61K 39/39 (2006.01); A61K 39/00 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 35/26 (2013.01); A61K 39/39 (2013.01); A61K 39/395 (2013.01); C07K 16/00 (2013.01); A61K 2039/515 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/55522 (2013.01); A61K 2039/55527 (2013.01); C07K 16/248 (2013.01); C07K 2317/14 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2321 (2013.01); C12N 2501/515 (2013.01); Y02A 50/30 (2018.01);
Abstract
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.