The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Nov. 22, 2019
Applicant:
Integrated Biotherapeutics, Inc., Rockville, MD (US);
Inventors:
Mohammad Javad Aman, Rockville, MD (US);
Rajan Prasad Adhikari, Rockville, MD (US);
Assignee:
INTEGRATED BIOTHERAPEUTICS, INC., Rockville, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/12 (2006.01); C12N 9/52 (2006.01); C07K 14/195 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1271 (2013.01); C07K 14/195 (2013.01); C12N 9/52 (2013.01); C12Y 304/24075 (2013.01); A61K 38/00 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/70 (2013.01);
Abstract
This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriolysin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.