The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
May. 22, 2017
Applicant:
Excivion Ltd., Cambridgeshire, GB;
Inventor:
Peter Laing, Cambridge, GB;
Assignee:
Excivion LTD, Willingham, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/18 (2006.01); A61P 31/14 (2006.01); A61K 39/12 (2006.01); G01N 33/569 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/1825 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); C07K 14/005 (2013.01); G01N 33/56983 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/53 (2013.01); C12N 2770/24122 (2013.01); C12N 2770/24134 (2013.01); G01N 2333/185 (2013.01);
Abstract
The invention relates to isolated recombinant analogues of flavivirus E-protein fusion loops comprising at least one glycosylation site for an N-linked glycan that is not present in the natural flavivirus E-protein fusion loop sequence, wherein the at least one glycosylation site is an N-linked glycosylation sequon (Asn-X-Ser/Thr) and the Asn (N) residue of the sequon occupies any of positions 98-110 (SEQ ID NO: 1) (DRGWGNGCGLFGK) of the natural flavivirus E-protein fusion loop amino acid sequence, wherein X is any amino acid residue except proline and Ser/Thr denotes a serine or threonine residue.