The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Jan. 29, 2018
Nippon Medical School Foundation, Tokyo, JP;
National Center of Neurology and Psychiatry, Tokyo, JP;
Takara Bio Inc., Shiga, JP;
Takashi Okada, Tokyo, JP;
Hironori Okada, Tokyo, JP;
Hiromi Kinoh, Tokyo, JP;
Tatsuji Enoki, Kusatsu, JP;
Toshikazu Nishie, Kusatsu, JP;
Junichi Mineno, Kusatsu, JP;
NIPPON MEDICAL SCHOOL FOUNDATION, Tokyo, JP;
NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, Tokyo, JP;
TAKARA BIO INC., Shiga, JP;
Abstract
The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the amino acid sequence for wild-type AAV capsid protein; a nucleic acid encoding the mutant; a cell containing the nucleic acid; a method for producing a recombinant AAV particle, comprising a step of culturing the cell to produce the recombinant AAV particle; a recombinant AAV particle containing the mutant; a composition containing the recombinant AAV particle; and a method for transferring a gene into a target cell, comprising a step of bringing the recombinant AAV particle into contact with the target cell.