The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Dec. 05, 2019
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 7/06 (2006.01); A61K 38/16 (2006.01); A61K 38/08 (2019.01); C07K 7/08 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61K 38/08 (2013.01); A61K 38/16 (2013.01); C07K 7/08 (2013.01); C07K 14/00 (2013.01); C07K 14/4746 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.