The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
May. 31, 2016
Applicant:
University of Iowa Research Foundation, Iowa City, IA (US);
Inventors:
Beverly L. Davidson, Iowa City, IA (US);
Megan S. Keiser, Iowa City, IA (US);
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); A61P 25/00 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61P 25/00 (2018.01); C07K 14/47 (2013.01); C12N 15/113 (2013.01); C12N 15/79 (2013.01); C12N 2310/141 (2013.01); C12N 2310/531 (2013.01); C12N 2320/32 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14143 (2013.01);
Abstract
The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant adeno-associated virus (rAAV) particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding a therapeutic agent inserted between a pair of AAV inverted terminal repeats in a manner effective to infect the CNS cell of the non-rodent mammal such that the CNS cell expresses the therapeutic agent in the non-rodent mammal.