The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Oct. 11, 2017
Km Biologies Co., Ltd., Kumamoto, JP;
Makoto Moriyama, Yamaga, JP;
Katsuhiko Fukada, Koshi, JP;
Kazuhiko Kimachi, Kumamoto, JP;
Yuki Mihara, Kumamoto, JP;
Hiroshi Yonemura, Kumamoto, JP;
Yoichiro Kino, Kumamoto, JP;
KM BIOLOGICS CO., LTD., Kumamoto, JP;
Abstract
A method for preparing a PRP conjugate having high storage stability and a method for producing a Hib conjugate vaccine are provided. A method for preparing PRP conjugate in accordance with the embodiments of the present invention is characterized by that the release of PRPs after preparing the PRP conjugate is suppressed by using PRP with a lowered molecular weight than native PRP for a coupling reaction between PRP and a carrier protein. Also, a Hib conjugate vaccine comprising as an antigen the PRP conjugate prepared by said method has excellent storage stability and maintain sufficient immunogenicity.