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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11026975 B1

PDFFull Text
Date of Patent:
Jun. 08, 2021

Filed:

Jan. 31, 2019

Chimeric antigen receptor (car) binding to bcma, and uses thereof

Applicants:

Nanjing Iaso Biotherapeutics Co., Ltd., Jiangsu, CN;

Innovent Biologics (Suzhou) Co., Ltd., Jiangsu, CN;

Inventors:

Jianfeng Zhou, Jiangsu, CN;

Junjian Liu, Jiangsu, CN;

Guang Hu, Jiangsu, CN;

Yongkun Yang, Jiangsu, CN;

Guangrong Meng, Jiangsu, CN;

Wenjing Gao, Jiangsu, CN;

Yuyu Wang, Jiangsu, CN;

Panpan Niu, Jiangsu, CN;

Assignees:

Nanjing IASO Biotherapeutics Co., Ltd., Jiangsu, CN;

Innovent Biologics (Suzhou) Co., Ltd., Jiangsu, CN;

Attorneys:

Honigman LLP

Thomas A. Wootton, Esq.

Jonathan P. O'Brien

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/63 (2006.01); C12N 15/62 (2006.01); A61K 39/395 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/54 (2013.01); C07K 14/70517 (2013.01); C07K 14/70575 (2013.01); C07K 14/715 (2013.01); C07K 16/28 (2013.01); C07K 19/00 (2013.01); C12N 5/10 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2319/03 (2013.01);
Abstract

The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.

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