The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Sep. 06, 2019
Applicants:
Epizyme, Inc., Cambridge, MA (US);
Health Research, Inc., Buffalo, NY (US);
Inventors:
Heike Keilhack, Belmont, MA (US);
Roberto Pili, Indianapolis, IN (US);
Assignees:
Epizyme, Inc., Cambridge, MA (US);
Health Research, Inc., Buffalo, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/404 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/4412 (2006.01); A61K 31/44 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/404 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4412 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents (such as tyrosine kinase inhibitors or VEGF/VEGFR inhibitors), particularly anticancer agents such as sunitinib, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.