The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Apr. 26, 2018
The Brigham and Women's Hospital, Inc., Boston, MA (US);
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Paul B. Yu, Boston, MA (US);
Wenwei Huang, Rockville, MD (US);
Philip Edward Sanderson, Bethesda, MD (US);
Jian-Kang Jiang, Columbia, MD (US);
Khalida Shamim, Gaithersburg, MD (US);
Wei Zheng, Potomac, MD (US);
Xiuli Huang, Potomac, MD (US);
Gregory Tawa, Doylestown, PA (US);
Arthur Lee, San Jose, CA (US);
Asaf Alimardanov, North Bethesda, MD (US);
Junfeng Huang, Woodstock, MD (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
The United States of America, as Represented by the Secretary, Dept, of Health and Human Services, Bethesda, MD (US);
Abstract
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).