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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11026891 B1

PDFFull Text
Date of Patent:
Jun. 08, 2021

Filed:

Aug. 15, 2017

Transmembrane ph-gradient polymersomes and their use in the scavenging of ammonia and its methylated analogs

Applicant:

Eth Zurich, Zurich, CH;

Inventors:

Jean-Christophe Leroux, Zurich, CH;

Simon Matoori, Zurich, CH;

Aaron Christoph Schmidt, Zurich, CH;

Assignee:

Eth Zurich, Zurich, CH;

Attorney:

Faegre Drinker Biddle & Reath LLP

Primary Examiner:

Sin J Lee

Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/00 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 31/194 (2006.01); A61P 9/00 (2006.01); A61P 5/00 (2006.01); A61P 43/00 (2006.01); A61P 3/00 (2006.01); A61P 25/00 (2006.01); A61P 13/12 (2006.01); A61P 13/02 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1273 (2013.01); A61K 9/0053 (2013.01); A61K 31/194 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61P 3/00 (2018.01); A61P 5/00 (2018.01); A61P 9/00 (2018.01); A61P 13/02 (2018.01); A61P 13/12 (2018.01); A61P 25/00 (2018.01); A61P 43/00 (2018.01);
Abstract

The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.

Find Patent Forward Citations

Leroux, Jean-Christophe. (2021). Transmembrane ph-gradient polymersomes and their use in the scavenging of ammonia and its methylated analogs (U.S. Patent No. 11026891). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11026891

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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