The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
May. 02, 2019
Applicant:
Glaxosmithkline Biologicals S.a., Rixensart, BE;
Inventors:
Luis Brito, Concord, MA (US);
Michelle C. Archer, Florence, MA (US);
Andrew Geall, Littleton, MA (US);
Derek O'Hagan, Winchester, MA (US);
Manmohan Singh, Cary, NC (US);
Assignee:
GlaxoSmithKline Biologicals SA, Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/107 (2006.01); A61K 31/713 (2006.01); A61K 39/12 (2006.01); A61K 39/155 (2006.01); A61K 9/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/107 (2013.01); A61K 31/713 (2013.01); A61K 39/12 (2013.01); A61K 39/155 (2013.01); A61K 9/0019 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55566 (2013.01); C12N 2760/18534 (2013.01); Y02A 50/30 (2018.01);
Abstract
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.