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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11021465 B1

PDFFull Text
Date of Patent:
Jun. 01, 2021

Filed:

Oct. 16, 2019

Dna-pk inhibitors

Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Paul S. Charifson, Framingham, MA (US);

Kevin Michael Cottrell, Cambridge, MA (US);

Hongbo Deng, Southborough, MA (US);

John P. Duffy, Northborough, MA (US);

Huai Gao, Arlington, MA (US);

Simon Giroux, Cambridge, MA (US);

Jeremy Green, Waltham, MA (US);

Katrina Lee Jackson, Cambridge, MA (US);

Joseph M. Kennedy, Charlestown, MA (US);

David J. Lauffer, Stow, MA (US);

Mark Willem Ledeboer, Acton, MA (US);

Pan Li, Lexington, MA (US);

John Patrick Maxwell, Hingham, MA (US);

Mark A. Morris, Somerville, MA (US);

Albert Charles Pierce, Cambridge, MA (US);

Nathan D. Waal, Cambridge, MA (US);

Jinwang Xu, Framingham, MA (US);

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED, Boston, MA (US);

Attorneys:

Andrea L. C. Reid

Danielle M. Nihan

Dechert LLP

Primary Examiner:

Tracy Vivlemore

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 409/04 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 491/056 (2006.01); C07D 495/04 (2006.01); C07D 521/00 (2006.01); C07D 239/42 (2006.01); C07D 417/10 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 47/55 (2017.01); A61K 47/54 (2017.01); A61K 31/53 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); A61K 41/00 (2020.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 41/0038 (2013.01); A61K 47/545 (2017.08); A61K 47/55 (2017.08); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 491/056 (2013.01); C07D 495/04 (2013.01); C07D 521/00 (2013.01);
Abstract

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

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