The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2021
Filed:
May. 17, 2018
Wigen Biomedicine Technology (Shanghai) Co., Ltd., Shanghai, CN;
Zhiyi Yao, Shanghai, CN;
Cheng Luo, Shanghai, CN;
Yuli Xie, Shanghai, CN;
Liyan Yue, Shanghai, CN;
Wei Wan, Shanghai, CN;
Yuanyuan Zhang, Shanghai, CN;
Hualiang Jiang, Shanghai, CN;
Kaixian Chen, Shanghai, CN;
WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD., Shanghai, CN;
Abstract
The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator.