IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11021456 B1

PDFFull Text
Date of Patent:
Jun. 01, 2021

Filed:

Dec. 30, 2019

Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds

Applicant:

Aerie Pharmaceuticals, Inc., Bedminster, NJ (US);

Inventors:

Mitchell A. deLong, Chapel Hill, NC (US);

Jill Marie Sturdivant, Chapel Hill, NC (US);

Susan M. Royalty, Davis, CA (US);

Assignee:

Aerie Pharmaceuticals, Inc., Bedminster, NJ (US);

Attorneys:

K&L Gates LLP

Louis C. Cullman

Benjamin D. Heuberger

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 333/24 (2006.01); C07D 213/56 (2006.01); C07D 237/04 (2006.01); C07D 417/12 (2006.01); C07D 413/12 (2006.01); C07D 409/12 (2006.01); C07D 405/12 (2006.01); C07D 401/12 (2006.01); C07D 217/24 (2006.01); A61K 31/4709 (2006.01); A61K 31/16 (2006.01); A61K 31/47 (2006.01); A61K 31/381 (2006.01); C07C 237/48 (2006.01); C07D 217/02 (2006.01); C07C 237/04 (2006.01);
U.S. Cl.
CPC ...
C07D 333/24 (2013.01); A61K 31/16 (2013.01); A61K 31/381 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); C07C 237/04 (2013.01); C07C 237/48 (2013.01); C07D 213/56 (2013.01); C07D 217/02 (2013.01); C07D 217/24 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.

Find Patent Forward Citations

Loading…