The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2021
Filed:
Jun. 11, 2019
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Ian S. Young, Redwood City, CA (US);
Sha Lou, North Brunswick, NJ (US);
Sanjeev Gangwar, Foster City, CA (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/00 (2006.01); A61K 47/68 (2017.01); C07K 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6811 (2017.08); C07K 5/10 (2013.01);
Abstract
In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.