The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 01, 2021

Filed:

Mar. 13, 2018
Applicants:

The Regents of the University of California, Oakland, CA (US);

Henry Ford Health System, Detroit, MI (US);

Inventors:

Phillip Crews, Santa Cruz, CA (US);

Frederick A. Valeriote, Washington, MI (US);

Sheng Lin, Beijing, CN;

Erin P. McCauley, Santa Cruz, CA (US);

Nicholas Lorig-Roach, Santa Cruz, CA (US);

Karen Tenney, Santa Cruz, CA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07D 471/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/437 (2013.01); A61P 35/00 (2018.01); C07D 471/06 (2013.01);
Abstract

Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.


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