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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11020381 B1

PDFFull Text
Date of Patent:
Jun. 01, 2021

Filed:

Aug. 31, 2018

Biaryloxy derivatives as ttx-s blockers

Applicants:

Raqualia Pharma Inc., Aichi, JP;

Xuanzhu Pharma Co., Ltd., Jinan, CN;

Inventors:

Kiyoshi Kawamura, Aichi, JP;

Tatsuya Yamagishi, Aichi, JP;

Yuji Shishido, Aichi, JP;

Mikio Morita, Aichi, JP;

Ryuichi Yamaguchi, Aichi, JP;

Masashi Ohmi, Aichi, JP;

Assignees:

RaQualia Pharma Inc., Aichi, JP;

XuanZhu Pharma Co., Ltd., Jinan, CN;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
A61K 31/4433 (2006.01); A61P 29/00 (2006.01); A61K 31/18 (2006.01); A61K 31/415 (2006.01); A61K 31/42 (2006.01); A61K 31/4418 (2006.01); A61K 31/4545 (2006.01); A61K 31/4965 (2006.01); A61K 31/505 (2006.01); C07D 213/64 (2006.01); C07D 213/647 (2006.01); C07D 231/12 (2006.01); C07D 239/34 (2006.01); C07D 241/18 (2006.01); C07D 261/08 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07C 311/51 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4433 (2013.01); A61K 31/18 (2013.01); A61K 31/415 (2013.01); A61K 31/42 (2013.01); A61K 31/4418 (2013.01); A61K 31/4545 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61P 29/00 (2018.01); C07C 311/51 (2013.01); C07D 213/64 (2013.01); C07D 213/647 (2013.01); C07D 231/12 (2013.01); C07D 239/34 (2013.01); C07D 241/18 (2013.01); C07D 261/08 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01);
Abstract

The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

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