The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Oct. 31, 2018
Applicant:
Litron Laboratories, Ltd., Rochester, NY (US);
Inventors:
Stephen D. Dertinger, Webster, NY (US);
Steven M. Bryce, Rochester, NY (US);
Jeffrey C. Bemis, Rochester, NY (US);
Assignee:
LITRON LABORATORIES LTD., Rochester, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/533 (2006.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); G01N 1/30 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6875 (2013.01); G01N 33/502 (2013.01); G01N 33/5014 (2013.01); G01N 33/5044 (2013.01); G01N 33/5076 (2013.01); G01N 33/533 (2013.01); G01N 33/6878 (2013.01); G01N 1/30 (2013.01);
Abstract
The present invention relates a simple method for evaluating free eukaryotic cell nuclei for biomarkers of DNA damage and/or transcription factor activation, activity, or expression levels and/or epigenetic modifications to chromatin or chromatin-associated factors. The invention also teaches useful strategies for combining nuclear biomarkers into a matrix of endpoints that are capable of elucidating genotoxicants' primary mode of DNA-damaging activity. Kits for conducting methods according to the invention are also described.