The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Dec. 20, 2019
Shyam S. Mohapatra, Lutz, FL (US);
Subhra Mohapatra, Lutz, FL (US);
Rasim Oytun Guldiken, Tampa, FL (US);
Rajesh R. Nair, Tampa, FL (US);
Tao Wang, Tampa, FL (US);
Shyam S. Mohapatra, Lutz, FL (US);
Subhra Mohapatra, Lutz, FL (US);
Rasim Oytun Guldiken, Tampa, FL (US);
Rajesh R. Nair, Tampa, FL (US);
Tao Wang, Tampa, FL (US);
University of South Florida, Tampa, FL (US);
TransGenex Nanobiotech, Inc., Lutz, FL (US);
Abstract
A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.