The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 25, 2021

Filed:

Oct. 19, 2018
Applicant:

Ventana Medical Systems, Inc., Tucson, AZ (US);

Inventors:

Yu-Heng Cheng, Northville, MI (US);

Lisa A. Jones, Tucson, AZ (US);

Jessica A. Wifall, Oro Valley, AZ (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06K 9/00 (2006.01); G01N 1/28 (2006.01); G06T 7/62 (2017.01); G06T 7/246 (2017.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01); G06T 7/00 (2017.01);
U.S. Cl.
CPC ...
G01N 1/2813 (2013.01); G01N 35/00663 (2013.01); G01N 35/1009 (2013.01); G06T 7/0012 (2013.01); G06T 7/246 (2017.01); G06T 7/62 (2017.01); G01N 2001/282 (2013.01); G01N 2035/00673 (2013.01); G01N 2035/1025 (2013.01); G06T 2207/30168 (2013.01);
Abstract

A real-time imaging method and system for monitoring an assay process performed on a biological sample is described. In some embodiments, the method and system can be used to measure and control a reagent volume confined to a space between a cover and a substrate, which is particularly useful for controlling for evaporation in a thin-film staining environment. In particular embodiments, the disclosed reagent volume sensing and replenishment method and system are resistant to system noises generated during operation, for example, system noise due to vibration, field of view blockage by dispenser systems, differences in reagent colors, and changing tissue colors.


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