The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Nov. 20, 2018
President and Fellows of Harvard College, Cambridge, MA (US);
Gökhan S. Hotamisligil, Wellesley, MA (US);
Mehmet F. Burak, Brighton, MA (US);
Feyza Engin, Madison, WI (US);
Scott B. Widenmaier, Brighton, MA (US);
Elisabeth Helen Roberts, Slough, GB;
Adrian Richard Moore, Slough, GB;
Carl Brendan Doyle, Slough, GB;
Ralph Adams, Slough, GB;
Karine Jeannine Madeleine Hervé, Vancouver, CA;
Shauna Mhairi Wales, Slough, GB;
Kerry Louise Tyson, Slough, GB;
Karen Inouye, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as 'aP2') for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.