The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Aug. 13, 2015
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Denise Sabatino, Havertown, PA (US);
Katherine A. High, Merion Station, PA (US);
Liron Elkouby, Wynnewood, PA (US);
Assignee:
THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/755 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 48/005 (2013.01); A61K 48/0008 (2013.01); A61K 48/0066 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01); C12N 2840/007 (2013.01);
Abstract
Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors.