The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Oct. 23, 2014
Applicant:
University of Notre Dame Du Lac, Notre Dame, IN (US);
Inventors:
Marvin J. Miller, South Bend, IN (US);
Cheng Ji, Buffalo Grove, IL (US);
Assignee:
UNIVERSITY OF NOTRE DAME DU LAC, Notre Dame, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/56 (2006.01); C07D 209/14 (2006.01); C07D 261/14 (2006.01); C07D 501/00 (2006.01); C07D 215/22 (2006.01); C07D 413/12 (2006.01); C07D 207/40 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 263/34 (2006.01); C07D 265/26 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
C07D 215/56 (2013.01); A61K 47/54 (2017.08); A61K 47/559 (2017.08); C07D 207/40 (2013.01); C07D 209/14 (2013.01); C07D 215/22 (2013.01); C07D 261/14 (2013.01); C07D 263/34 (2013.01); C07D 265/26 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 501/00 (2013.01);
Abstract
A compound is provided, comprising: an Fe(III)-binding or an Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; a drug; and an Fe(III) to Fe(II) reduction triggered linker bound to the drug and the linker or, if no linker is present, then bound to the drug and the siderophore. Compositions and methods including the compound are also provided.