The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Nov. 04, 2016
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL (US);
Christopher R. Cogle, Gainesville, FL (US);
Amy M. Meacham, Gainesville, FL (US);
Peter P. Sayeski, Gainesville, FL (US);
Marcello A. Giulianotti, Port St. Lucie, FL (US);
Richard A. Houghten, Port St. Lucie, FL (US);
Gregory S. Welmaker, Port St. Lucie, FL (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL (US);
Abstract
Cancer is a disease for which there remains a great unmet medical need, and therefore the discovery and development of new antineoplastic agents is critically important. The present invention relates in part to new therapeutic compounds with antineoplastic activity. Provided herein are polyamine sulfonamides such as compounds of Formula (I), or pharmaceutically acceptable salts thereof, which may be used in the treatment and/or prevention of diseases such as cancer. Also provided herein are pharmaceutical compositions and kits comprising the inventive compounds. Furthermore, the present invention provides methods of treating and/or preventing diseases (e.g., cancer) using compounds of Formula (I), or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof. Other methods provided include methods for inducing apoptosis of a cell, as well as methods for inhibiting alpha-enolase enzymatic activity in vivo and in vitro.