The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Mar. 20, 2020
Applicant:
Roche Sequencing Solutions, Inc., Pleasanton, CA (US);
Inventors:
Dmitriy Gremyachinskiy, San Francisco, CA (US);
Peter Crisalli, Sunnyvale, CA (US);
Andrew Trans, Mountain View, CA (US);
Ashwini Bhat, Milpitas, CA (US);
Assignee:
Roche Sequencing Solutions, Inc., Pleasanton, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6869 (2018.01); C12Q 1/6823 (2018.01); C07H 21/04 (2006.01); C07H 19/10 (2006.01); C07H 19/06 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 21/04 (2013.01); C07K 14/00 (2013.01); C12Q 1/6823 (2013.01);
Abstract
The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.