The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 18, 2021

Filed:

Dec. 17, 2018
Applicant:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Inventors:

Slav Dugenny, San Leandro, CA (US);

Ellen H Fiss, Albany, CA (US);

Marc Rehfuss, Los Gatos, CA (US);

Assignee:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); C12Q 1/18 (2006.01); C12Q 1/6897 (2018.01); C12N 1/20 (2006.01); C12Q 1/66 (2006.01); C12N 7/00 (2006.01); C12Q 1/14 (2006.01); C12N 15/86 (2006.01); C12N 15/74 (2006.01); C12Q 1/70 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/18 (2013.01); C12N 1/20 (2013.01); C12N 7/00 (2013.01); C12N 15/74 (2013.01); C12N 15/86 (2013.01); C12Q 1/14 (2013.01); C12Q 1/66 (2013.01); C12Q 1/6897 (2013.01); C12Q 1/70 (2013.01); C12N 2795/10152 (2013.01); C12N 2795/10343 (2013.01); C12N 2795/10352 (2013.01);
Abstract

Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.


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