The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Dec. 28, 2018
Applicant:
Adimab, Llc, Lebanon, NH (US);
Inventors:
Maximiliano Vasquez, Lebanon, NH (US);
Michael Feldhaus, Lebanon, NH (US);
Tillman U. Gerngross, Lebanon, NH (US);
K. Dane Wittrup, Lebanon, NH (US);
Assignee:
Adimab, LLC, Lebanon, NH (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 50/06 (2006.01); C12N 15/10 (2006.01); C07K 16/00 (2006.01); C40B 40/08 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1093 (2013.01); C07K 16/00 (2013.01); C07K 16/005 (2013.01); C07K 2317/21 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C40B 40/08 (2013.01); C40B 50/06 (2013.01);
Abstract
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.