The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Oct. 11, 2018
Applicant:
Innovative Cellular Therapeutics Holdings, Ltd., Grand Cayman, KY;
Assignee:
Innovative Cellular Therapeutics Holdings, Ltd., Grand Cayman, KY;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/55 (2006.01); C12N 9/22 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C12N 9/10 (2006.01); C12N 15/62 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C12N 9/10 (2013.01); C12N 15/52 (2013.01); C12N 15/625 (2013.01); C12Y 301/21 (2013.01); C07K 2319/81 (2013.01);
Abstract
The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.