The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 18, 2021

Filed:

Jul. 05, 2018
Applicants:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

NY State Psychiatric Institute, New York, NY (US);

Inventors:

Kirsten Alison Rinderspacher, Mount Vernon, NY (US);

Wai Yu, New York, NY (US);

Karen Duff, New York, NY (US);

Donald Landry, New York, NY (US);

Shi-Xian Deng, White Plains, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); A61P 25/28 (2006.01); A61K 31/517 (2006.01); C07D 217/22 (2006.01); C07D 239/86 (2006.01); C07D 239/88 (2006.01); C07D 239/93 (2006.01); C07D 239/94 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/517 (2013.01); A61P 25/28 (2018.01); C07D 217/22 (2013.01); C07D 239/86 (2013.01); C07D 239/88 (2013.01); C07D 239/93 (2013.01); C07D 239/94 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract

The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.


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