The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Apr. 18, 2017
Genzyme Corporation, Cambridge, MA (US);
Elyse Bourque, Blaine, WA (US);
Mario A. Cabrera-Salazar, Brighton, MA (US);
Cassandra Celatka, Hull, MA (US);
Seng H. Cheng, Natick, MA (US);
Bradford Hirth, Littleton, MA (US);
Andrew Good, Wallingford, CT (US);
Katherine Jancsics, Wilmington, MA (US);
John Marshall, Charlestown, MA (US);
Markus Metz, Encinitas, CA (US);
Ronald K. Scheule, Hopkinton, MA (US);
Renato Skerlj, W. Newton, MA (US);
Yibin Xiang, Dracut, MA (US);
Zhong Zhao, Wayland, MA (US);
John Leonard, Manchester, NH (US);
Thomas Natoli, Revere, MA (US);
Elina Makino, Winchester, MA (US);
Herve Husson, Boston, MA (US);
Oxana Beskrovnaya, Southborough, MA (US);
GENZYME CORPORATION, Cambridge, MA (US);
Abstract
The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.