The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Mar. 15, 2018
Applicants:
Fondazione Istituto Italiano Di Tecnologia, Genoa, IT;
Universita′ Degli Studi Di Padova, Padua, IT;
Inventors:
Marco De Vivo, Genoa, IT;
Jose Antonio Ortego Martinez, Genoa, IT;
Claudia Sissi, Cadoneghe, IT;
Jose Manuel Arencibia Jimenez, Genoa, IT;
Assignees:
UNIVERSITÀ DEGLI STUDI DI PADOVA, Padua, IT;
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, Genoa, IT;
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/66 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 239/66 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention relates to a class of 5-carboxamide-2-thiobarbituric acid derivatives which inhibits human type II topoisomerase (topoII) enzyme and to use thereof as medicaments especially for blocking the proliferation of cancer cells and treating cancer. The invention also provides a method for the manufacture of the 5-carboxamide-2-thiobarbituric acid derivatives.