The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 18, 2021

Filed:

Jun. 21, 2019
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Karl Deisseroth, Stanford, CA (US);

Feng Zhang, Cambridge, MA (US);

Edward Boyden, Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61N 5/06 (2006.01); C12N 13/00 (2006.01); C12N 5/071 (2010.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61N 5/06 (2013.01); A61N 5/0601 (2013.01); A61N 5/0613 (2013.01); A61N 5/0622 (2013.01); C12N 5/0602 (2013.01); C12N 13/00 (2013.01); G01N 33/502 (2013.01); G01N 33/6872 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0647 (2013.01); A61N 2005/0652 (2013.01); A61N 2005/0663 (2013.01); A61N 2005/0665 (2013.01);
Abstract

Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.


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