The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Mar. 28, 2018
The Regents of the University of California, Oakland, CA (US);
Joseph Wang, San Diego, CA (US);
Berta Esteban-Fernández de Ávila, San Diego, CA (US);
Yi Chen, La Jolla, CA (US);
Chava Angell, La Jolla, CA (US);
Fernando Soto, La Jolla, CA (US);
Liangfang Zhang, San Diego, CA (US);
Malthe Hansen-Bruhn, Aarhus, DK;
THE REGENTS OF THE UNIVERSITY OF CALIFORNA, Oakland, CA (US);
Abstract
Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.