The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
Mar. 17, 2016
Applicant:
Vrije Universiteit Brussel, Brussels, BE;
Inventors:
Marinee Chuah, Bierbeek, BE;
Thierry Vandendriessche, Bierbeek, BE;
Assignee:
Vrije Universiteit Brussel, Brussels, BE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/86 (2006.01); C07K 14/755 (2006.01); C12N 9/64 (2006.01); C07K 14/745 (2006.01); C12N 15/85 (2006.01); A61K 38/37 (2006.01); A61K 38/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 38/37 (2013.01); A61K 38/4846 (2013.01); A61K 48/0066 (2013.01); C07K 14/745 (2013.01); C07K 14/755 (2013.01); C12N 9/644 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14343 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01); C12N 2830/36 (2013.01); C12N 2830/42 (2013.01); C12N 2830/85 (2013.01);
Abstract
The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor IX or factor VIII transgenes, methods employing these expression cassettes and vectors and uses thereof. The present invention is particularly useful for applications using liver-directed gene therapy, in particular for the treatment of hemophilia A and B.