The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
May. 12, 2018
Applicant:
Duke University, Durham, NC (US);
Inventors:
Ru-Rong Ji, Durham, NC (US);
Gang Chen, Durham, NC (US);
Zilong Wang, Durham, NC (US);
Changyu Jiang, Durham, NC (US);
Kaiyuan Wang, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 31/485 (2006.01); A61P 25/04 (2006.01); A61B 5/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A61B 5/4824 (2013.01); A61B 5/4848 (2013.01); A61K 31/485 (2013.01); A61P 25/04 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.