The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 18, 2021

Filed:

Jun. 25, 2018
Applicant:

General Electric Company, Schenectady, NY (US);

Inventors:

Anup Sood, Clifton Park, NY (US);

Lisa Anne Lowery, Niskayuna, NY (US);

Praveena Mohan, Clifton Park, NY (US);

James Edward Rothman, Niskayuna, NY (US);

John Donald Burczak, Voorheesville, NY (US);

Hae Won Lim, Niskayuna, NY (US);

Assignee:

GENERAL ELECTRIC COMPANY, Schenetady, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/64 (2017.01); A61K 31/713 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61K 41/00 (2020.01); C12N 15/87 (2006.01); C12N 15/11 (2006.01); A61K 9/00 (2006.01); A61K 47/06 (2006.01); A61M 37/00 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 9/0019 (2013.01); A61K 41/0028 (2013.01); A61K 47/06 (2013.01); A61K 47/554 (2017.08); A61K 47/64 (2017.08); A61K 47/643 (2017.08); A61K 47/6925 (2017.08); A61M 37/0092 (2013.01); C12N 15/111 (2013.01); C12N 15/1136 (2013.01); C12N 15/87 (2013.01); A61M 2037/0007 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01);
Abstract

The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.


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