The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 2021
Filed:
Jun. 26, 2017
Excilone, Elancourt, FR;
Université DE Cergy Pontoise, Cergy Pontoise, FR;
Université Evry Val D'essonne, Evry, FR;
Assistance Publique-hôpitaux DE Paris, Paris, FR;
Juan Pelta, Elancourt, FR;
Abdelghani Oukhaled, Elancourt, FR;
Philippe Manivet, Elancourt, FR;
Fabien Piguet, Elancourt, FR;
Hadjer Ouldali, Elancourt, FR;
Zuzana Krupova, Elancourt, FR;
Pierre Defrenaix, Elancourt, FR;
EXCILONE, Elancourt, FR;
UNIVERSITÉ DE CERGY PONTOISE, Cergy Pontoise, FR;
UNIVERSITÉ EVRY VAL D'ESSONNE, Evry, FR;
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS, Paris, FR;
Abstract
An aerolysin nanopore or a nanotube is used for the electrical detection of peptides, proteins separated by at least one amino acid and other macromolecules such as polysaccharides or synthetic or natural polymers present in a preparation where said nanopore or nanotube is inserted into a lipid membrane which is subjected to a difference in potential greater than −160 mV, in a reaction medium having an alkali metal halide electrolyte solution with a concentration of less than 6M and at a temperature of less than 40° C., and where said use is intended to differentiate said peptides, proteins and other molecules according to their length and their mass. Application to the sequencing of peptides and other molecules to differentiate them according to their length and mass with an amino acid-level or monomer-level resolution and to medical diagnosis.