The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 2021
Filed:
Jul. 15, 2016
Applicant:
Daiichi Sankyo Company, Limited, Tokyo, JP;
Inventors:
Yoshirou Kawaguchi, Shinagawa-ku, JP;
Kensuke Nakamura, Shinagawa-ku, JP;
Yukiko Sekiguchi, Shinagawa-ku, JP;
Mitsuhiro Iwamoto, Shinagawa-ku, JP;
Assignee:
Daiichi Sankyo Company, Limited, Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); C12P 21/02 (2006.01); C12N 15/09 (2006.01); C12N 15/02 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); C07K 16/32 (2013.01); C12N 15/02 (2013.01); C12N 15/09 (2013.01); C12P 21/02 (2013.01); C12Y 302/01096 (2013.01); C07K 2317/41 (2013.01);
Abstract
The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.