The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 11, 2021

Filed:

Feb. 26, 2018
Applicant:

Achillion Pharmaceuticals, Inc., New Haven, CT (US);

Inventors:

Jason Allan Wiles, Madison, CT (US);

Avinash S. Phadke, Branford, CT (US);

Milind Deshpande, Madison, CT (US);

Atul Agarwal, Hamden, CT (US);

Dawei Chen, Guilford, CT (US);

Venkat Rao Gadhachanda, Hamden, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Godwin Pais, Hamden, CT (US);

Qiuping Wang, Bethany, CT (US);

Xiangzhu Wang, Branford, CT (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/6512 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 403/14 (2006.01); A61P 27/02 (2006.01); A61P 1/16 (2006.01); A61P 9/00 (2006.01); A61P 19/02 (2006.01); A61P 11/00 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07F 9/6512 (2013.01); A61P 1/16 (2018.01); A61P 9/00 (2018.01); A61P 11/00 (2018.01); A61P 19/02 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, or a pharmaceutically acceptable salt or composition thereof. The inhibitors of Factor D described herein reduce the excessive activation of complement, and are useful to treat disorders mediated by the complement system.


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