The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 2021
Filed:
Sep. 13, 2019
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventor:
Brian S. Lucas, Thousand Oaks, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 59/56 (2006.01); C07C 59/68 (2006.01); C07D 513/10 (2006.01); C07D 513/08 (2006.01); C07D 498/00 (2006.01);
U.S. Cl.
CPC ...
C07D 513/10 (2013.01); C07C 59/56 (2013.01); C07C 59/68 (2013.01); C07D 498/00 (2013.01); C07D 513/08 (2013.01);
Abstract
Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.