The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 11, 2021

Filed:

Jan. 20, 2017
Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Ian Stansfield, Issy-les Moulineaux, FR;

Olivier Alexis Georges Querolle, Issy-les Moulineaux, FR;

Gerhard Max Gross, Beerse, BE;

Edgar Jacoby, Beerse, BE;

Lieven Meerpoel, Beerse, BE;

Janusz Jozef Kulagowski, Harlow, GB;

Calum Macleod, Harlow, GB;

Samuel Edward Mann, Harlow, GB;

Simon Richard Green, Harlow, GB;

George Hynd, Harlow, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract

The present invention relates to pharmaceutical agents of formula (I), useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as a cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.


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