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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11000581 B1

PDFFull Text
Date of Patent:
May. 11, 2021

Filed:

Apr. 28, 2017

Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (omvs) for delivery to the gi-tract

Applicants:

Quadram Institute Bioscience, Norwich, GB;

Uea Enterprises Limited, Norwich, GB;

Inventors:

Regis Gabriel Stentz, Norwich, GB;

Simon Richard Carding, Norwich, GB;

Assignees:

QUADRAM INSTITUTE BIOSCIENCE, Norwich, GB;

UEA ENTERPRISES LIMITED, Norwich, GB;

Attorney:

Crowe & Dunlevy, P.C.

Primary Examiner:

Albert M Navarro

Assistant Examiner:

Mark Navarro

Int. Cl.
CPC ...
A01N 63/00 (2020.01); A61K 39/02 (2006.01); C12N 9/24 (2006.01); C12N 15/74 (2006.01); C12N 1/20 (2006.01); A61K 35/74 (2015.01); A61K 39/112 (2006.01); C12P 21/02 (2006.01); A61P 31/04 (2006.01); C12N 15/52 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0216 (2013.01); A61K 35/74 (2013.01); A61K 39/0275 (2013.01); A61P 31/04 (2018.01); C12N 1/20 (2013.01); C12N 9/2488 (2013.01); C12N 15/52 (2013.01); C12N 15/74 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); A61K 2039/541 (2013.01); A61K 2039/6068 (2013.01); C07K 2319/02 (2013.01);
Abstract

This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.

Find Patent Forward Citations

Stentz, Regis. (2021). Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (omvs) for delivery to the gi-tract (U.S. Patent No. 11000581). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11000581

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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