The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Apr. 06, 2012
Applicants:
Koji Azuma, Naruto, JP;
Yasutaka Fujita, Naruto, JP;
Hiroshi Yaguchi, Naruto, JP;
Miwa Harada, Naruto, JP;
Inventors:
Koji Azuma, Naruto, JP;
Yasutaka Fujita, Naruto, JP;
Hiroshi Yaguchi, Naruto, JP;
Miwa Harada, Naruto, JP;
Assignee:
OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); C07K 14/705 (2013.01); C07K 2319/30 (2013.01); C12N 2500/02 (2013.01); C12N 2533/50 (2013.01);
Abstract
The present invention provides a method of producing a sheet-like pancreatic islet, comprising culturing an isolated pancreatic islet in a culture vessel, wherein a polypeptide comprising an EC1 domain of E-cadherin and having a binding ability to said E-cadherin is fixed on or applied to a surface of a solid phase, while being adhered to the solid phase surface for a period sufficient for the pancreatic islet to take a sheet-like form.