The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Mar. 18, 2015
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Luis Avila, Arlington, MA (US);
Clark Pan, Sutton, MA (US);
Huawei Qiu, Westborough, MA (US);
Qun Zhou, Ashland, MA (US);
Assignee:
GENZYME CORPORATION, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/32 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); A61K 47/68 (2017.01); A61K 47/61 (2017.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 47/60 (2017.08); A61K 47/61 (2017.08); A61K 47/6803 (2017.08); A61K 47/6855 (2017.08); A61K 47/6889 (2017.08); C07K 16/2851 (2013.01); C07K 16/2893 (2013.01); C07K 16/40 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/71 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01);
Abstract
The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.