The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 04, 2021

Filed:

May. 24, 2018
Applicant:

Cantargia Ab, Lund, SE;

Inventors:

Thoas Fioretos, Lund, SE;

Marcus Järås, Lund, SE;

Assignee:

Cantargia AB, Lund, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 47/68 (2017.01); A61K 51/10 (2006.01); C12N 15/115 (2010.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 47/6849 (2017.08); A61K 51/1027 (2013.01); A61K 51/1033 (2013.01); A61K 51/1093 (2013.01); C07K 16/28 (2013.01); C07K 16/30 (2013.01); C07K 16/3061 (2013.01); C12N 15/115 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/732 (2013.01);
Abstract

The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of cells associated with a solid tumour, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological cells associated with a solid tumour, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same.


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