The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Apr. 19, 2020
Immunobrain Checkpoint, Inc., Dover, DE (US);
Yeda Research and Development Co. Ltd., Rehovot, IL;
Ester Yoles, Beit-Gamliel, IL;
Berit Olsen Krogh, Valby, DK;
Allan Jensen, Valby, DK;
Jan Egebjerg, Valby, DK;
Carol David, Rehovot, IL;
Kuti Baruch, Ness Ziona, IL;
Michal Eisenbach-Schwartz, Rehovot, IL;
ImmunoBrain Checkpoint, Inc., Dover, DE (US);
Yeda Research and Development Co. Ltd., Rehovot, IL;
Abstract
The present specification discloses modified anti-PD-L1 antibodies that abolishes Fc-related effector function and enhances clearance rate while maintaining therapeutic efficacy for neurodegenerative disease modification. The present specification also discloses nucleic acid sequences and expression constructs encoding such modified anti-PD-L1 antibodies as well as methods of making such modified anti-PD-L1 antibodies. In addition, the present specification discloses methods of treatment and uses that employ an administration regime of the disclosed anti-PD-L1 antibodies that ensures the antibodies are present for only a specific period of time and then are sufficiently cleared from the body to ensure treatment efficacy is maintained.