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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10993945 B1

PDFFull Text
Date of Patent:
May. 04, 2021

Filed:

Mar. 09, 2016

Cdk8-cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

Applicant:

Senex Biotechnology, Inc., Columbia, SC (US);

Inventors:

Igor B Roninson, Lexington, SC (US);

Donald C Porter, Columbia, SC (US);

Assignee:

SENEX BIOTECHNOLOGY, INC., Columbia, SC (US);

Attorney:

Quarles & Brady LLP

Primary Examiner:

Yong S Chong

Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 45/06 (2006.01); A61K 31/535 (2006.01); A61K 31/495 (2006.01); A61K 31/5377 (2006.01); C07D 239/94 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61K 31/495 (2013.01); A61K 31/535 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 239/94 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57415 (2013.01); G01N 33/57449 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4739 (2013.01); G01N 2333/91205 (2013.01);
Abstract

The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases. The invention provides new compounds having improved solubility and/or potency, and methods for their use. In various aspects, the invention relates to the treatment of cancer. The invention provides methods for chemoprevention and prevention of tumor recurrence or metastasis. The invention further provides diagnostic techniques for treatment for certain cancer types. The invention utilizes specific inhibitors of CDK8/19 and/or measurement of CDK8 levels in a patient.

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