The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Dec. 29, 2017
Applicant:
Agency for Science, Technology and Research, Singapore, SG;
Inventors:
Assignee:
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61P 35/00 (2006.01); A61K 47/61 (2017.01); A61K 33/243 (2019.01); A61K 9/51 (2006.01); A61K 31/282 (2006.01); A61K 31/41 (2006.01); A61K 31/555 (2006.01); A61K 47/69 (2017.01); A61K 31/665 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5036 (2013.01); A61K 9/5123 (2013.01); A61K 31/282 (2013.01); A61K 31/41 (2013.01); A61K 31/555 (2013.01); A61K 31/665 (2013.01); A61K 33/243 (2019.01); A61K 47/61 (2017.08); A61K 47/6907 (2017.08); A61P 35/00 (2018.01);
Abstract
There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.