The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2021
Filed:
Oct. 14, 2016
Applicant:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Inventors:
Samuel Pendergraft, Winston-Salem, NC (US);
Hooman Sadri-Ardekani, Lewisville, NC (US);
Anthony Atala, Winston-Salem, NC (US);
Colin Bishop, Clemmons, NC (US);
Assignee:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/22 (2006.01); A01N 1/02 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A01N 1/021 (2013.01); A01N 1/0221 (2013.01); C12N 5/0697 (2013.01); C12N 2506/246 (2013.01); C12N 2510/04 (2013.01); C12N 2533/90 (2013.01); G01N 2500/10 (2013.01); G01N 2510/00 (2013.01); G01N 2520/00 (2013.01);
Abstract
A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.